BDBM440444 US10633389, Example 109-3::US20230279020, Example 109-3

SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CC3(C2)CCN(CC3)C(=O)OC)c(C)c(n1)-c1c(C)noc1C

InChI Key InChIKey=OWCOTUVKROVONT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 440444   

TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of FLAG-tagged CARM1 (unknown origin) (2 to 585 residues) using biotin-aminohexanoate-PRKQLATKAARMeKSAP-amide peptide as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CARM1 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 6nMAssay Description:Inhibition of flag-tagged PRMT4 (2 to 585 residues) (unknown origin) expressed in HEK293F cells preincubated for 30 mins followed by biotinylated sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 6nMAssay Description:Inhibition of C-terminal FLAG-tagged N-terminal His tagged CARM1 (unknown origin) (2 to 585 residues) expressed in HEK293F cells using biotin-aminohe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 6nMAssay Description:Inhibition of FLAG-tagged CARM1 (unknown origin) (2 to 585 residues) using biotin-aminohexanoate-PRKQLATKAARMeKSAP-amide peptide as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 6nMAssay Description:Inhibition of FLAG tagged CARM1 (2 to 585 residues) (unknown origin) using SAM as substrate preincubated for 30 mins followed by substrate addition b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 18nMAssay Description:Inhibition of PRMT4 in human RPMI-8226 cells assessed as reduction in SMB methylation incubated for 96 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 38nMAssay Description:Inhibition of PRMT4 in human RPMI-8226 cells assessed as reduction in PABP1 methylation incubated for 96 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 73nMAssay Description:Inhibition of PRMT4 in human MDA-MB-231 cells assessed as decrease in BAF155 methylation level incubated for 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 1(Human)
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT1 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed