BDBM4424 (4S,5S)-4,5-dihydroxy-2,7-bis({[2-(2-phenylethyl)phenyl]methyl})-1,2,7-thiadiazepane-1,1-dione::cyclic sulfamide, biaryl analog 11

SMILES O[C@H]1CN(Cc2ccccc2CCc2ccccc2)S(=O)(=O)N(Cc2ccccc2CCc2ccccc2)C[C@@H]1O

InChI Key InChIKey=QXWNLYOSFSKBKQ-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4424   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University

LigandPNGBDBM4424((4S,5S)-4,5-dihydroxy-2,7-bis({[2-(2-phenylethyl)p...)
Affinity DataKi:  3.00E+3nM ΔG°:  -7.66kcal/molepH: 5.0 T: 2°CAssay Description:The effects of the inhibitors on the activity of HIV-1 proteinase was determined by a fluorometric assay with an internally quenched fluorescent pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed