BDBM443505 US10660877, Example 82

SMILES CCc1c([nH]c2ccc(C3CCNCC3)c(C)c12)-c1ccnc(C)c1

InChI Key InChIKey=IPIPJCBHPFVOGC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 443505   

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443505(US10660877, Example 82)
Affinity DataIC50: 7.30nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2021
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443505(US10660877, Example 82)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443505(US10660877, Example 82)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443505(US10660877, Example 82)
Affinity DataIC50: 29.2nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2021
Entry Details
US Patent