BDBM443897 3-isopropyl-2-(2-methoxypyridin-4-yl)-5-(piperidin-4-yl)-1H-indole::US10660877, Example 485

SMILES COc1cc(ccn1)-c1[nH]c2ccc(cc2c1C(C)C)C1CCNCC1

InChI Key InChIKey=KAGSPINYGPNPCN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 443897   

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443897(US10660877, Example 485 | 3-isopropyl-2-(2-methoxy...)
Affinity DataIC50: 11.8nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2021
Entry Details
US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443897(US10660877, Example 485 | 3-isopropyl-2-(2-methoxy...)
Affinity DataIC50: 34.8nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2021
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443897(US10660877, Example 485 | 3-isopropyl-2-(2-methoxy...)
Affinity DataIC50: 74nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443897(US10660877, Example 485 | 3-isopropyl-2-(2-methoxy...)
Affinity DataIC50: 93nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443897(US10660877, Example 485 | 3-isopropyl-2-(2-methoxy...)
Affinity DataIC50: 3.04E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2021
Entry Details
US Patent