BDBM444221 US10660877, Example 811

SMILES Cc1cc(-c2[nH]c3ccc(C4CCN(C5CCN(C(C)C)CC5)CC4)cc3c2C)ccn1

InChI Key InChIKey=GKENUMJCKKDCSN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 444221   

TargetToll-like receptor 9(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 444221BDBM444221(US10660877, Example 811)
Affinity DataIC50: 23nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2021
Entry Details
US Patent

TargetToll-like receptor 8(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 444221BDBM444221(US10660877, Example 811)
Affinity DataIC50: 47.2nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2021
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 444221BDBM444221(US10660877, Example 811)
Affinity DataIC50: 117nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2021
Entry Details
US Patent