BDBM4445 4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile::4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile::6,7-dialkoxyquinoline-3-carbonitrile deriv. 8::CHEMBL111038
SMILES COc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1OC
InChI Key InChIKey=CQKFTSMPIIYOBX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 4445
Affinity DataIC50: 190nMpH: 7.4 T: 22°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 191nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 2.40nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human EGFR kinase activityMore data for this Ligand-Target Pair