BDBM444920 6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-::US10668067, Example 1-81

SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=OOABYMBLTSLHBH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 444920   

TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444920(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444920(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Affinity DataIC50: 143nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444920(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Affinity DataIC50: 9.00E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444920(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed