BDBM445772 US10669240, Compound 68::US10669240, Compound 69

SMILES COc1ccc(NC(=O)c2n[nH]c3ccc(cc23)-c2cncc(CN3CCCCC3)c2)cn1

InChI Key InChIKey=YDPWZFPXWFTXNT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 445772   

TargetDual specificity protein kinase CLK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM445772(US10669240, Compound 69 | US10669240, Compound 68)
Affinity DataIC50: 0.822nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProto-oncogene Wnt-1(Human)
Samumed

US Patent
LigandPNGBDBM445772(US10669240, Compound 69 | US10669240, Compound 68)
Affinity DataIC50: 45nMAssay Description:Reporter cell lines were generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a W...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetProto-oncogene Wnt-1(Human)
Samumed

US Patent
LigandPNGBDBM445772(US10669240, Compound 69 | US10669240, Compound 68)
Affinity DataIC50: 57nMAssay Description:Reporter cell lines were generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a W...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent