BDBM448386 1-[(6-{6,6-Difluoro-3-azabicyclo[3.1.0]hexan-3-yl}-::US10695334, Example 15
SMILES COCc1nn(Cc2ccc(nc2C)N2CC3C(C2)C3(F)F)cc1C(=O)N[C@@H]1CCc2c(C)n[nH]c12
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 448386
Affinity DataKi: 0.100nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair