BDBM448933 N-(5-(4-Aminopiperidine-1-yl)pyridin-2-yl)-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-amine::US10696678, Example 28

SMILES CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(cn2)N2CCC(N)CC2)ncc1F

InChI Key InChIKey=BUYWCTZLOSQWIK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 448933   

TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448933(N-(5-(4-Aminopiperidine-1-yl)pyridin-2-yl)-5-fluor...)
Affinity DataIC50: 64nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448933(N-(5-(4-Aminopiperidine-1-yl)pyridin-2-yl)-5-fluor...)
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448933(N-(5-(4-Aminopiperidine-1-yl)pyridin-2-yl)-5-fluor...)
Affinity DataIC50: 2.80E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent