BDBM450877 N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-1-methyl-8-(4-(methylsulfonyl)phenyl)imidazo[1,5-c]pyrimidin-5-amine::US10676479, Example 4

SMILES Cc1ncn2c(NCc3c4CCOc4ccc3F)ncc(-c3ccc(cc3)S(C)(=O)=O)c12

InChI Key InChIKey=RZHMGYHYURIAFB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450877   

LigandChemical structure of BindingDB Monomer ID 450877BDBM450877(US10676479, Example 4 | N-((5-fluoro-2,3-dihydrobe...)
Affinity DataIC50: 15.6nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450877BDBM450877(US10676479, Example 4 | N-((5-fluoro-2,3-dihydrobe...)
Affinity DataIC50: 29.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450877BDBM450877(US10676479, Example 4 | N-((5-fluoro-2,3-dihydrobe...)
Affinity DataIC50: 32.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent