BDBM450970 Ethyl 5-((2,4-difluoro-5-methoxybenzyl)amino)-8-(4-(methylsulfonyl)phenyl)imidazo[1,5-c]pyrimidine-1-carboxylate::US10676479, Example 7

SMILES CCc1ncn2c(NCc3cc(OC)c(F)cc3F)ncc(-c3ccc(cc3)S(C)(=O)=O)c12

InChI Key InChIKey=LVLBRKQPTQCXPF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450970   

LigandChemical structure of BindingDB Monomer ID 450970BDBM450970(US10676479, Example 7 | Ethyl 5-((2,4-difluoro-5-m...)
Affinity DataIC50: 16.8nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450970BDBM450970(US10676479, Example 7 | Ethyl 5-((2,4-difluoro-5-m...)
Affinity DataIC50: 16.8nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450970BDBM450970(US10676479, Example 7 | Ethyl 5-((2,4-difluoro-5-m...)
Affinity DataIC50: 236nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent