BDBM450979 8-(2,4-dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-1-(oxazol-2-yl)imidazo[1,5-c]pyrimidin-5-amine::US10676479, Example 11

SMILES Cc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnc(-c3ncco3)c12

InChI Key InChIKey=YPQWPAMAYXWZLK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450979   

LigandChemical structure of BindingDB Monomer ID 450979BDBM450979(US10676479, Example 11 | 8-(2,4-dimethylpyrimidin-...)
Affinity DataIC50: 6.90nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450979BDBM450979(US10676479, Example 11 | 8-(2,4-dimethylpyrimidin-...)
Affinity DataIC50: 12.6nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450979BDBM450979(US10676479, Example 11 | 8-(2,4-dimethylpyrimidin-...)
Affinity DataIC50: 17.1nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent