BDBM450983 8-(2,4-dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-::US10676479, Example 15

SMILES Cc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnc(S(=O)c3ccccc3)c12

InChI Key InChIKey=BGXWGWQDFNTTNZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450983   

LigandChemical structure of BindingDB Monomer ID 450983BDBM450983(US10676479, Example 15 | 8-(2,4-dimethylpyrimidin-...)
Affinity DataIC50: 7.80nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450983BDBM450983(US10676479, Example 15 | 8-(2,4-dimethylpyrimidin-...)
Affinity DataIC50: 15.2nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450983BDBM450983(US10676479, Example 15 | 8-(2,4-dimethylpyrimidin-...)
Affinity DataIC50: 29.8nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent