BDBM451022 8-(4-(difluoromethyl)pyridin-3-yl)-N-((5-fluoro-::US10676479, Example 52

SMILES FC(F)c1ccncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cncc12

InChI Key InChIKey=VMZXSOBKAQBAKX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451022   

LigandChemical structure of BindingDB Monomer ID 451022BDBM451022(US10676479, Example 52 | 8-(4-(difluoromethyl)pyri...)
Affinity DataIC50: 10.2nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451022BDBM451022(US10676479, Example 52 | 8-(4-(difluoromethyl)pyri...)
Affinity DataIC50: 17.8nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451022BDBM451022(US10676479, Example 52 | 8-(4-(difluoromethyl)pyri...)
Affinity DataIC50: 42.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent