BDBM451027 8-(6-(difluoromethyl)-2-methylpyridin-3-yl)-N-((5-::US10676479, Example 57

SMILES Cc1nc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cncc12)C(F)F

InChI Key InChIKey=FSWCLCIVYVNCKT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451027   

LigandChemical structure of BindingDB Monomer ID 451027BDBM451027(US10676479, Example 57 | 8-(6-(difluoromethyl)-2-m...)
Affinity DataIC50: 7.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451027BDBM451027(US10676479, Example 57 | 8-(6-(difluoromethyl)-2-m...)
Affinity DataIC50: 12.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451027BDBM451027(US10676479, Example 57 | 8-(6-(difluoromethyl)-2-m...)
Affinity DataIC50: 54.1nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent