BDBM451059 5-((2,4-difluoro-5-methoxybenzyl)amino)-8-(2-::US10676479, Example 89

SMILES COc1cc(CNc2ncc(-c3cccnc3C)c3c(ncn23)C#N)c(F)cc1F

InChI Key InChIKey=AEZJCGGDYOTQKJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451059   

LigandChemical structure of BindingDB Monomer ID 451059BDBM451059(US10676479, Example 89 | 5-((2,4-difluoro-5-methox...)
Affinity DataIC50: 29.6nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451059BDBM451059(US10676479, Example 89 | 5-((2,4-difluoro-5-methox...)
Affinity DataIC50: 42.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451059BDBM451059(US10676479, Example 89 | 5-((2,4-difluoro-5-methox...)
Affinity DataIC50: 195nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent