BDBM451083 1-(2,6-dimethylpyridin-3-yl)-8-(2,4-::US10676479, Example 113

SMILES Cc1ccc(-c2ncn3c(NCc4c5CCOc5ccc4F)ncc(-c4cnc(C)nc4C)c23)c(C)n1

InChI Key InChIKey=DCRVHULDTVKEEV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451083   

LigandChemical structure of BindingDB Monomer ID 451083BDBM451083(US10676479, Example 113 | 1-(2,6-dimethylpyridin-3...)
Affinity DataIC50: 15.2nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451083BDBM451083(US10676479, Example 113 | 1-(2,6-dimethylpyridin-3...)
Affinity DataIC50: 38.9nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451083BDBM451083(US10676479, Example 113 | 1-(2,6-dimethylpyridin-3...)
Affinity DataIC50: 53.1nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent