BDBM451097 US10676485, Example 7

SMILES CN1CCN(C[C@@H]2COc3ccc(OCc4ccnc(n4)-c4ccc(OC[C@@H]5COCCO5)cc4)c(C[C@@H](Oc4ncnc5sc(c(-c6c(C)c(Cl)c(O2)c(Cl)c6C)c45)-c2ccc(F)cc2)C(O)=O)c3)CC1

InChI Key InChIKey=BOMNURVTAHAEBQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 451097   

LigandPNGBDBM451097(US10676485, Example 7)
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM451097(US10676485, Example 7)
Affinity DataKi:  0.0360nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451097(US10676485, Example 7)
Affinity DataKi:  0.920nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetBcl-2-related protein A1(Human)TBA
LigandPNGBDBM451097(US10676485, Example 7)
Affinity DataKi: >468nMAssay Description:Binding affinity to Bfl-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)TBA
LigandPNGBDBM451097(US10676485, Example 7)
Affinity DataKi: >468nMAssay Description:Binding affinity to Bcl-W (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM451097(US10676485, Example 7)
Affinity DataKi:  599nMAssay Description:Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)TBA
LigandPNGBDBM451097(US10676485, Example 7)
Affinity DataKi: >660nMAssay Description:Binding affinity to Bcl-xL (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed