BDBM451753 4-(6-amino-5-(4-oxo-3,4- dihydroquinazolin-7- yl)pyridin-3-yl)-N- cyclopropyl-3-fluoro-N- methylbenzenesulfonamide::US10710978, Compound I-63

SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2c(c1)nc[nH]c2=O

InChI Key InChIKey=KQHLACSPINNCQV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451753   

TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451753(4-(6-amino-5-(4-oxo-3,4- dihydroquinazolin-7- yl)p...)
Affinity DataIC50: <40nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase 26(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451753(4-(6-amino-5-(4-oxo-3,4- dihydroquinazolin-7- yl)p...)
Affinity DataIC50: >1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase 24(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451753(4-(6-amino-5-(4-oxo-3,4- dihydroquinazolin-7- yl)p...)
Affinity DataIC50: >1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451753(4-(6-amino-5-(4-oxo-3,4- dihydroquinazolin-7- yl)p...)
Affinity DataIC50: >1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent