BDBM454282 (Z)-5-(1-(4-amino-2-fluorobut-2-en-1-yl)- 4-chloro-2-methyl-1H-indol-3-yl)-N,N- dimethylpyridine-3-sulfonamide::US10717733, Compound 75::US11098045, Compound 75

SMILES CN(C)S(=O)(=O)c1cncc(c1)-c1c(C)n(C\C(F)=C\CN)c2cccc(Cl)c12

InChI Key InChIKey=BGUIUILVCOCCOJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 454282   

TargetLysyl oxidase homolog 2(Human)
Pharmaxis

US Patent
LigandPNGBDBM454282((Z)-5-(1-(4-amino-2-fluorobut-2-en-1-yl)- 4-chloro...)
Affinity DataIC50: 300nMAssay Description:LOX and LOXL2: Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetOxidized low-density lipoprotein receptor 1(Bovine)
Pharmaxis

US Patent
LigandPNGBDBM454282((Z)-5-(1-(4-amino-2-fluorobut-2-en-1-yl)- 4-chloro...)
Affinity DataIC50: 300nMAssay Description:LOX and LOXL2: Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetOxidized low-density lipoprotein receptor 1(Bovine)
Pharmaxis

US Patent
LigandPNGBDBM454282((Z)-5-(1-(4-amino-2-fluorobut-2-en-1-yl)- 4-chloro...)
Affinity DataIC50: 300nMAssay Description:LOX: The assay was developed using either 384 or 96 well format. Briefly, in a standard 384 well plate assay 25 μL of a dilution of any of the i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmaxis

US Patent
LigandPNGBDBM454282((Z)-5-(1-(4-amino-2-fluorobut-2-en-1-yl)- 4-chloro...)
Affinity DataIC50: 300nMAssay Description:LOX: The assay was developed using either 384 or 96 well format. Briefly, in a standard 384 well plate assay 25 μL of a dilution of any of the i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetAmine oxidase [copper-containing] 3(Human)
Pharmaxis

US Patent
LigandPNGBDBM454282((Z)-5-(1-(4-amino-2-fluorobut-2-en-1-yl)- 4-chloro...)
Affinity DataIC50: 3.00E+3nMAssay Description:Human recombinant SSAO/VAP-1 amine oxidase activity was determined using the coupled colorimetric method as described for monoamine oxidase, copper-c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetAmine oxidase [copper-containing] 3(Human)
Pharmaxis

US Patent
LigandPNGBDBM454282((Z)-5-(1-(4-amino-2-fluorobut-2-en-1-yl)- 4-chloro...)
Affinity DataIC50: 3.00E+3nMAssay Description:Human recombinant SSAO/VAP-1 amine oxidase activity was determined using the coupled colorimetric method as described for monoamine oxidase, copper-c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Pharmaxis

US Patent
LigandPNGBDBM454282((Z)-5-(1-(4-amino-2-fluorobut-2-en-1-yl)- 4-chloro...)
Affinity DataIC50: 3.00E+3nMAssay Description:Mao-B: The specificity of the compounds of this invention was tested by determining their ability to inhibit MAO-B activities in vitro. Recombinant h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Pharmaxis

US Patent
LigandPNGBDBM454282((Z)-5-(1-(4-amino-2-fluorobut-2-en-1-yl)- 4-chloro...)
Affinity DataIC50: 3.00E+3nMAssay Description:MAO-B: The specificity of the compounds of this invention was tested by determining their ability to inhibit MAO-B activities in vitro. Recombinant h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent