BDBM454873 US10730870, Example 36::US11512083, Example 36

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2CCCCC2)C(C)(C)C)cc1

InChI Key InChIKey=HSEHJNACVZBYIS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 454873   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454873BDBM454873(US10730870, Example 36 | US11512083, Example 36)
Affinity DataIC50: 3.55E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetVHL complex(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454873BDBM454873(US10730870, Example 36 | US11512083, Example 36)
Affinity DataIC50: 3.55E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetVHL complex(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454873BDBM454873(US10730870, Example 36 | US11512083, Example 36)
Affinity DataIC50: 5.48E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454873BDBM454873(US10730870, Example 36 | US11512083, Example 36)
Affinity DataIC50: 5.48E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454873BDBM454873(US10730870, Example 36 | US11512083, Example 36)
Affinity DataIC50: 6.54E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetVHL complex(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454873BDBM454873(US10730870, Example 36 | US11512083, Example 36)
Affinity DataIC50: 6.54E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent