BDBM454914 US10730870, Example 81::US11512083, Example 81

SMILES COc1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](C(C)C)N2Cc3ccccc3C2=O)cc1

InChI Key InChIKey=PDXUBEWQSIEGOD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 454914   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454914BDBM454914(US10730870, Example 81 | US11512083, Example 81)
Affinity DataIC50: 4.90E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetVHL complex(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454914BDBM454914(US10730870, Example 81 | US11512083, Example 81)
Affinity DataIC50: 4.90E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454914BDBM454914(US10730870, Example 81 | US11512083, Example 81)
Affinity DataIC50: 3.71E+5nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetVHL complex(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454914BDBM454914(US10730870, Example 81 | US11512083, Example 81)
Affinity DataIC50: 3.71E+5nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent