BDBM456221 (R)-6-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihydroisobenzofuran-5- yl)ethyl)amino)methyl) thiazol-2-yl)-4- methylnicotinonitrile::US10723723, Example 128

SMILES Cc1cc(ncc1C#N)-c1ncc(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)s1

InChI Key InChIKey=NBABYGWJJCNTGT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 456221   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456221((R)-6-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...)
Affinity DataIC50: 6.60nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456221((R)-6-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed