BDBM458585 US10745401, Example 59::US11466007, Example 59

SMILES Cn1ncc2CCN(CCN3CCN(CC3)c3nsc4ccccc34)C(=O)c12

InChI Key InChIKey=QQXHQQJZRPYPBM-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 458585   

Target5-hydroxytryptamine receptor 2A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM458585(US10745401, Example 59 | US11466007, Example 59 | ...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM458585(US10745401, Example 59 | US11466007, Example 59 | ...)
Affinity DataKi:  0.450nMAssay Description:Binding inhibition rate for 5-HT1A receptor (%)=100−100×{(Binding amount of [3H]8-OH-DPAT in the presence of test compound)}−(Binding amount of [3H]8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM458585(US10745401, Example 59 | US11466007, Example 59 | ...)
Affinity DataKi:  0.450nMAssay Description:Present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following procedures. CHO cell membrane ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM458585(US10745401, Example 59 | US11466007, Example 59 | ...)
Affinity DataKi:  1.99nMAssay Description:Binding inhibition rate for 5-HT1A receptor (%)=100−100×{(Binding amount of [3H]8-OH-DPAT in the presence of test compound)}−(Binding amount of [3H]8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM458585(US10745401, Example 59 | US11466007, Example 59 | ...)
Affinity DataKi:  1.99nMAssay Description:Present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following procedures. CHO cell membrane ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM458585(US10745401, Example 59 | US11466007, Example 59 | ...)
Affinity DataKi:  1.99nMAssay Description:Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM458585(US10745401, Example 59 | US11466007, Example 59 | ...)
Affinity DataKi:  125nMAssay Description:Binding inhibition rate for 5-HT1A receptor (%)=100−100×{(Binding amount of [3H]8-OH-DPAT in the presence of test compound)}−(Binding amount of [3H]8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM458585(US10745401, Example 59 | US11466007, Example 59 | ...)
Affinity DataKi:  125nMAssay Description:Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM458585(US10745401, Example 59 | US11466007, Example 59 | ...)
Affinity DataKi:  125nMAssay Description:Present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following procedures. CHO cell membrane ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent