BDBM458632 5-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]ethyl}-3-methoxy-2-methyl-2,5,6,7-tetrahydro-4H-pyrazolo[4,3-c]pyridin-4-one::US10745401, Example 106::US11466007, Example 106

SMILES COc1c2c(CCN(CCN3CCN(CC3)c3nsc4ccccc34)C2=O)nn1C

InChI Key InChIKey=SJAVWFDEBXEFCQ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 458632   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Sumitomo Pharma

US Patent
LigandPNGBDBM458632(5-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  0.460nMAssay Description:Present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following procedures. CHO cell membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Sumitomo Pharma

US Patent
LigandPNGBDBM458632(5-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM458632(5-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  1.63nMAssay Description:Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM458632(5-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  1.63nMAssay Description:Present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following procedures. CHO cell membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Sumitomo Pharma

US Patent
LigandPNGBDBM458632(5-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  804nMAssay Description:Present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following procedures. CHO cell membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Sumitomo Pharma

US Patent
LigandPNGBDBM458632(5-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  804nMAssay Description:Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent