BDBM462 4-({6-[2-(4-aminophenyl)ethyl]-4-hydroxy-2-oxo-6-(propan-2-yl)-5,6-dihydro-2H-pyran-3-yl}sulfanyl)-5-tert-butyl-2-methylphenyl N-ethylsulfamate::6-Alkyl-5,6-Dihydropyran-2-one 29::CHEMBL305204::Dihydropyran-2-one deriv. 67

SMILES CCNS(=O)(=O)Oc1cc(c(SC2C(=O)CC(CCc3ccc(N)cc3)(OC2=O)C(C)C)cc1C)C(C)(C)C

InChI Key InChIKey=GGNHFKBTBQMCPR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 462   

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM462(4-({6-[2-(4-aminophenyl)ethyl]-4-hydroxy-2-oxo-6-(...)
Affinity DataIC50: 4.30nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM462(4-({6-[2-(4-aminophenyl)ethyl]-4-hydroxy-2-oxo-6-(...)
Affinity DataIC50: 4.30nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM462(4-({6-[2-(4-aminophenyl)ethyl]-4-hydroxy-2-oxo-6-(...)
Affinity DataIC50: 4.30nMpH: 6.2 T: 2°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2004
Entry Details Article
PubMed