BDBM4620 Anilinoquinazoline deriv. 3::N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine

SMILES COc1cc2ncnc(Nc3ccc(Cl)cc3)c2cc1OC

InChI Key InChIKey=LHGGYEWCVWOGFX-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 4620   

LigandChemical structure of BindingDB Monomer ID 4620BDBM4620(N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 283nMAssay Description:Inhibition of human NOD1 expressed in HEK-Blue hNOD1 cells coexpressing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of NF-kappaB tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4620BDBM4620(N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 800nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4620BDBM4620(N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant His-tagged VEGFR2 assessed as infrared absorption by ELISA assay in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4620BDBM4620(N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 800nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 4620BDBM4620(N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NOD2 expressed in HEK-Blue hNOD2 cells coexpressing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of TNF-alpha in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 4620BDBM4620(N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NOD2 expressed in HEK-Blue hNOD2 cells coexpressing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of NF-kappaB tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 4620BDBM4620(N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 1.10E+4nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
AstraZeneca

LigandChemical structure of BindingDB Monomer ID 4620BDBM4620(N-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine...)
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed