BDBM462212 (Scheme F-7): Preparation of 2-[(3R,4R)-4-{[4-(3-tert-butyl-3H-imidazo[4,5-b]pyridin-5-yl)-5-chloropyridin-2-yl]amino}-3-hydroxypiperidin-1-yl]-N-methylacetamide::US10766884, Example F30::US11220494, Example F30

SMILES CC(C)(C)n1cnc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)C(=O)C2(N)CC(F)(F)C2)ncc1Cl

InChI Key InChIKey=PBEICQQHXUBGMD-SJLPKXTDSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 462212   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM462212((Scheme F-7): Preparation of 2-[(3R,4R)-4-{[4-(3-t...)
Affinity DataKi:  0.5nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM462212((Scheme F-7): Preparation of 2-[(3R,4R)-4-{[4-(3-t...)
Affinity DataKi:  0.5nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM462212((Scheme F-7): Preparation of 2-[(3R,4R)-4-{[4-(3-t...)
Affinity DataKi:  12.5nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM462212((Scheme F-7): Preparation of 2-[(3R,4R)-4-{[4-(3-t...)
Affinity DataKi:  12.5nMAssay Description:CDK6/Cyclin D3: The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent