BDBM463164 4-(4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-6-oxo- 6,7-dihydro-5H-pyrrolo[2,3- d]pyrimidin-5-yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 18-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(C#N)c(F)c1

InChI Key InChIKey=NOUXVMMDCFQWPT-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463164   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463164(4-(4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]...)
Affinity DataKi:  0.168nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent