BDBM463297 4-amino-2-(8-{2- fluorobenzyl}imidazo- [1,2-a]pyrazin-6-yl)- 5-(4-hydroxy-5- (trifluoromethyl)- pyridin-2-yl)-5-methyl- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 146-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(cn1)C(F)(F)F

InChI Key InChIKey=QDLOQGYQYPORIM-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463297   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463297(4-amino-2-(8-{2- fluorobenzyl}imidazo- [1,2-a]pyra...)
Affinity DataKi:  0.378nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent