BDBM464159 3-((3-(4-(1H-pyrazol- 4-yl)phenyl)-2-oxo-8- oxa-1,3- diazaspiro[4.5]decan- 1-yl)methyl)-N- (cyclopropylmethyl) benzamide::US10787450, Example 37

SMILES O=C(NCC1CC1)c1cccc(CN2C(=O)N(CC22CCOCC2)c2ccc(cc2)-c2cn[nH]c2)c1

InChI Key InChIKey=ITTZXRRSMSYDEH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464159   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464159(3-((3-(4-(1H-pyrazol- 4-yl)phenyl)-2-oxo-8- oxa-1,...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent