BDBM464571 Preparation of 1-(1-allylcyclopropylsulfonyl)-6-bromo-N-((4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-1H-indole-4-carboxamide ::US10793549, Compound G-46

SMILES C=CCC1(S(=O)(=O)n2ccc3c(C(=O)NCc4c(C)cc(C)[nH]c4=O)cc(-c4ccc(N5CCN(C)CC5)nc4)cc32)CC1

InChI Key InChIKey=GBXMRSWKFIOOTI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 464571   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 464571BDBM464571(1-(1-allylcyclopropylsulfonyl)-6-bromo-N-((4, 6-di...)
Affinity DataIC50: 52nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 464571BDBM464571(1-(1-allylcyclopropylsulfonyl)-6-bromo-N-((4, 6-di...)
Affinity DataIC50: 52nMAssay Description:Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 464571BDBM464571(1-(1-allylcyclopropylsulfonyl)-6-bromo-N-((4, 6-di...)
Affinity DataIC50: 8.70E+5nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed