BDBM466434 (8S)-N-[(1S)-1-(4- cyano-2-methoxy- phenyl)ethyl]-5- (7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 5-azaspiro [2.5]octane- 8-carboxamide::US10799507, Example 97

SMILES COc1cc(ccc1[C@H](C)NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C#N

InChI Key InChIKey=FXPUFSFDZXFVQO-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466434   

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandPNGBDBM466434((8S)-N-[(1S)-1-(4- cyano-2-methoxy- phenyl)ethyl]-...)
Affinity DataEC50:  8.70nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM466434((8S)-N-[(1S)-1-(4- cyano-2-methoxy- phenyl)ethyl]-...)
Affinity DataEC50:  36nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM466434((8S)-N-[(1S)-1-(4- cyano-2-methoxy- phenyl)ethyl]-...)
Affinity DataEC50:  226nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM466434((8S)-N-[(1S)-1-(4- cyano-2-methoxy- phenyl)ethyl]-...)
Affinity DataEC50:  315nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent