BDBM466449 N-[[1-(cyanomethyl) cyclopropyl] methyl]- 5-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 5-azaspiro [2.5]octane- 8-carboxamide::US10799507, Example 112

SMILES O=C(NCC1(CC#N)CC1)C1CCN(CC11CC1)c1ncnc2[nH]ccc12

InChI Key InChIKey=NZAYCCODVLCHOI-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466449   

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandPNGBDBM466449(N-[[1-(cyanomethyl) cyclopropyl] methyl]- 5-(7H-py...)
Affinity DataEC50:  11.3nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM466449(N-[[1-(cyanomethyl) cyclopropyl] methyl]- 5-(7H-py...)
Affinity DataEC50:  32.7nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM466449(N-[[1-(cyanomethyl) cyclopropyl] methyl]- 5-(7H-py...)
Affinity DataEC50:  46nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM466449(N-[[1-(cyanomethyl) cyclopropyl] methyl]- 5-(7H-py...)
Affinity DataEC50:  518nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent