BDBM466561 N-{2-[6-(Trifluoromethyl)-3′,6′-dihydro[2,4′-bipyridin]-1′ (2′H)-yl]ethyl}-tetrahydro-2H-pyran-3-carboxamide::US10800755, Example 16::US11014905, Example 16

SMILES FC(F)(F)c1cccc(n1)C1=CCN(CCNC(=O)C2CCCOC2)CC1

InChI Key InChIKey=LUQGVAHGIPCKGZ-UHFFFAOYSA-N

Data  3 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 466561   

TargetD(2) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466561(N-{2-[6-(Trifluoromethyl)-3′,6′-dihydr...)
Affinity DataKi:  6nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466561(N-{2-[6-(Trifluoromethyl)-3′,6′-dihydr...)
Affinity DataIC50: 6nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466561(N-{2-[6-(Trifluoromethyl)-3′,6′-dihydr...)
Affinity DataKi:  27nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466561(N-{2-[6-(Trifluoromethyl)-3′,6′-dihydr...)
Affinity DataIC50: 27nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466561(N-{2-[6-(Trifluoromethyl)-3′,6′-dihydr...)
Affinity DataEC50:  31nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466561(N-{2-[6-(Trifluoromethyl)-3′,6′-dihydr...)
Affinity DataEC50:  43nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466561(N-{2-[6-(Trifluoromethyl)-3′,6′-dihydr...)
Affinity DataKi:  1.69E+3nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466561(N-{2-[6-(Trifluoromethyl)-3′,6′-dihydr...)
Affinity DataIC50: 1.69E+3nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466561(N-{2-[6-(Trifluoromethyl)-3′,6′-dihydr...)
Affinity DataIC50: 1.00E+4nMAssay Description:The activity of the present compound for inhibiting hERG channel was measured by whole-cell patch clamp method with auto patch clamp system, using CH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent