BDBM466903 US10800769, Example 6::methyl tetrahydropyran- 4-yl ({6-[(3R)-3-methyl- morpholin-4-yl]-2-{1H- pyrrolo[2,3-b]pyridin-4- yl}pyrimidin-4-yl}- imino)-lambda6-sulfanone
SMILES C[C@@H]1COCCN1c1cc(N=S(C)(=O)C2CCOCC2)nc(-c2ccnc3[nH]ccc23)n1
InChI Key InChIKey=YQUDFCUTBNDZAV-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 466903
TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of human full-length FLAG-TEV-tagged ATR/His6-tagged ATRIP expressed in HEK293 cells using FAM-labeled RAD17 peptide and ATP as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 212nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 213nMAssay Description:Inhibition of ATR in 4-NQO treated human HT-29 cells assessed as inhibition of Chk1 phosphorylation at Ser345 residue incubated for 90 mins followed ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 6.36E+3nMAssay Description:Inhibition of mTOR in human HT-29 cells assessed as inhibition of S6 ribosomal protein phosphorylation at Ser 235/236 residue incubated for 2 hrsMore data for this Ligand-Target Pair