BDBM467142 (8-cyclopentyl-2-{[(methylsulfonyl)piperidin-4-yl]amino}-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)acetonitrile::US10800783, Example 135::US11396512, Example 135

SMILES CCOC(=O)Cc1cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc2n(C2CCCC2)c1=O

InChI Key InChIKey=BZIPLHUWHXTOMK-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 467142   

LigandPNGBDBM467142((8-cyclopentyl-2-{[(methylsulfonyl)piperidin-4-yl]...)
Affinity DataKi:  0.440nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
US Patent

LigandPNGBDBM467142((8-cyclopentyl-2-{[(methylsulfonyl)piperidin-4-yl]...)
Affinity DataKi:  0.440nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

LigandPNGBDBM467142((8-cyclopentyl-2-{[(methylsulfonyl)piperidin-4-yl]...)
Affinity DataKi:  0.840nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

LigandPNGBDBM467142((8-cyclopentyl-2-{[(methylsulfonyl)piperidin-4-yl]...)
Affinity DataKi:  0.840nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
US Patent