BDBM470833 (1S,3''R,6''R,7''R,8''E,11''S,12''R)- 7''-(((9aR)-8-acetyloctahydro- 2H-pyrazino[1,2-a]pyrazin-2- yl)methyl)-6-chloro-7''- methoxy-11'',12''-dimethyl-3,4- dihydro-2H,15''H- spiro[naphthalene-1,22''- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15''-one 13'',13''-dioxide::US10821115, Example 218::US10821115, Example 229::US10821115, Example 230::US11224601, Example 230

SMILES CO[C@]1(CN2CCN3CCN(C[C@@H]3C2)C(C)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=UZIPFCZITGTKOC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 470833   

LigandPNGBDBM470833((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 7''-(((9aR)-...)
Affinity DataIC50: 0.0510nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM470833((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 7''-(((9aR)-...)
Affinity DataIC50: 0.0510nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM470833((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 7''-(((9aR)-...)
Affinity DataIC50: 0.142nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM470833((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 7''-(((9aR)-...)
Affinity DataIC50: 0.142nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM470833((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 7''-(((9aR)-...)
Affinity DataIC50: 0.619nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM470833((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 7''-(((9aR)-...)
Affinity DataIC50: 0.619nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent