BDBM470846 (1S,3''R,6''R,7''S,8''E,11''S,12''R)- 6-chloro-7''-(((9aS)-2,2- dioxidohexahydropyrazino[2,1- c][1,4]thiazin-8(1H)- yl)methyl)-7''-methoxy-11'',12''- dimethyl-3,4-dihydro-2H,15''H- spiro[naphthalene-1,22''- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15''-one 13'',13''-dioxide::US10821115, Example 231::US10821115, Example 232::US11224601, Example 232

SMILES CO[C@@]1(CN2CCN3CCS(=O)(=O)C[C@@H]3C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=XMYXXXSKQQVSOQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 470846   

LigandPNGBDBM470846(US10821115, Example 232 | (1S,3''R,6''R,7''S,8''E,...)
Affinity DataIC50: 0.0610nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM470846(US10821115, Example 232 | (1S,3''R,6''R,7''S,8''E,...)
Affinity DataIC50: 0.0610nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM470846(US10821115, Example 232 | (1S,3''R,6''R,7''S,8''E,...)
Affinity DataIC50: 0.141nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM470846(US10821115, Example 232 | (1S,3''R,6''R,7''S,8''E,...)
Affinity DataIC50: 0.141nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent