BDBM470893 (3R)-3-(4- (((1S,3'R,6'R,7'S,8'E,11'S, 12'R)-6-chloro-7'-methoxy- 11',12'-dimethyl-13',13'- dioxido-15'-oxo-3,4-dihydro- 2H-spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 7'-yl)methyl)-1-piperazinyl)-5- hydroxypentanoic acid::US10821115, Example 278::US11224601, Example 278

SMILES CO[C@@]1(CN2CCN(CC2)[C@H](CCO)CC(O)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=RVTHXACUVRWBPD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470893   

LigandPNGBDBM470893(US10821115, Example 278 | (3R)-3-(4- (((1S,3'R,6'R...)
Affinity DataIC50: 0.0390nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM470893(US10821115, Example 278 | (3R)-3-(4- (((1S,3'R,6'R...)
Affinity DataIC50: 0.0390nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent