BDBM470963 (1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-((9aS)- hexahydropyrazino[2,1- c][1,4]oxazin-8(1H)-ylmethyl)- 12'-(2-hydroxyethyl)-7'- methoxy-11'-methyl-3,4- dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15'-one 13',13'-dioxide::US10821115, Example 346::US11224601, Example 346

SMILES CO[C@@]1(CN2CCN3CCOC[C@@H]3C2)\C=C\C[C@H](C)[C@@H](CCO)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=OMLFPPSIEVDHNS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470963   

LigandPNGBDBM470963((1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-((9aS)...)
Affinity DataIC50: 0.0620nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM470963((1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-((9aS)...)
Affinity DataIC50: 0.0620nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent