BDBM471005 US10821115, Example 100018::US10821115, Example 100320::US10821115, Example 100353::US11224601, Example 100353

SMILES C[C@H]1C\C=C\[C@@](O)(C#CCN2CCOCC2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C

InChI Key InChIKey=QUTXQDXJEBXSPT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 471005   

LigandPNGBDBM471005(US10821115, Example 100320 | US10821115, Example 1...)
Affinity DataIC50: 0.0610nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM471005(US10821115, Example 100320 | US10821115, Example 1...)
Affinity DataIC50: 0.0610nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM471005(US10821115, Example 100320 | US10821115, Example 1...)
Affinity DataIC50: 0.348nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM471005(US10821115, Example 100320 | US10821115, Example 1...)
Affinity DataIC50: 0.348nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM471005(US10821115, Example 100320 | US10821115, Example 1...)
Affinity DataIC50: 1.20nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM471005(US10821115, Example 100320 | US10821115, Example 1...)
Affinity DataIC50: 1.20nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent