BDBM471107 US10821115, Example 100120::US10821115, Example 100121::US10821115, Example 100122::US10821115, Example 100123::US11224601, Example 100123

SMILES C[C@@H](C(O)=O)[C@@]1(O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=QWCWTPWSQMYUCF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 471107   

LigandPNGBDBM471107(US10821115, Example 100122 | US10821115, Example 1...)
Affinity DataIC50: 0.0560nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM471107(US10821115, Example 100122 | US10821115, Example 1...)
Affinity DataIC50: 0.0560nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM471107(US10821115, Example 100122 | US10821115, Example 1...)
Affinity DataIC50: 0.0670nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM471107(US10821115, Example 100122 | US10821115, Example 1...)
Affinity DataIC50: 0.0670nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM471107(US10821115, Example 100122 | US10821115, Example 1...)
Affinity DataIC50: 0.0920nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM471107(US10821115, Example 100122 | US10821115, Example 1...)
Affinity DataIC50: 0.0920nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM471107(US10821115, Example 100122 | US10821115, Example 1...)
Affinity DataIC50: 0.0980nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM471107(US10821115, Example 100122 | US10821115, Example 1...)
Affinity DataIC50: 0.0980nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent