BDBM47418 4-[(E)-3-(2-fluorophenyl)-1-oxoprop-2-enyl]-1-methyl-5,6,7,8-tetrahydro-2H-isoquinolin-3-one::4-[(E)-3-(2-fluorophenyl)acryloyl]-1-methyl-5,6,7,8-tetrahydro-2H-isoquinolin-3-one::4-[(E)-3-(2-fluorophenyl)prop-2-enoyl]-1-methyl-5,6,7,8-tetrahydro-2H-isoquinolin-3-one::4-[3-(2-fluorophenyl)acryloyl]-1-methyl-5,6,7,8-tetrahydro-3(2H)-isoquinolinone::MLS000575604::SMR000185742::cid_5721594

SMILES CC[C@H]1CCC[C@@]1(N)COc4cc(c2cnc3cccc(C#N)n23)cc(SC)c4C#N

InChI Key InChIKey=YXZKKQAZJWYKNB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 47418   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47418BDBM47418(US20240124450, Example 7)
Affinity DataIC50: 0.5nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47418BDBM47418(US20240124450, Example 7)
Affinity DataIC50: 0.800nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47418BDBM47418(US20240124450, Example 7)
Affinity DataIC50: 1.80nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent