BDBM47423 US20240124450, Example 10A

SMILES CC[C@@H]1CCC[C@@]1(N)COc4cc(c2cnc3cccc(OC)n23)cc(SC)c4C#N

InChI Key InChIKey=BIYKGGOFJOFQIZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 47423   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47423BDBM47423(US20240124450, Example 10A)
Affinity DataIC50: 3.5nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47423BDBM47423(US20240124450, Example 10A)
Affinity DataIC50: 5.30nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47423BDBM47423(US20240124450, Example 10A)
Affinity DataIC50: 16.4nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent