BDBM47435 2-methyl-3-[(E)-1-oxo-3-phenylprop-2-enyl]-1H-quinolin-4-one::2-methyl-3-[(E)-3-phenylacryloyl]-4-quinolone::2-methyl-3-[(E)-3-phenylprop-2-enoyl]-1H-quinolin-4-one::3-cinnamoyl-2-methyl-4(1H)-quinolinone::MLS000689897::SMR000298594::cid_5350830

SMILES CC[C@H]4CCC[C@](N)(COc3cc(c1cnc2cccc(OC)n12)cc(OC)c3C#N)C4

InChI Key InChIKey=GLMXCYNQAMJMGO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 47435   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47435BDBM47435(US20240124450, Example 17B)
Affinity DataIC50: 0.200nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47435BDBM47435(US20240124450, Example 17B)
Affinity DataIC50: 0.400nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47435BDBM47435(US20240124450, Example 17B)
Affinity DataIC50: 1.20nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent