BDBM475093 US10851082, NUCC-0054131

SMILES COc1cccc(c1)-n1cc(cn1)-c1ccnc(NCCc2ccncc2)n1

InChI Key InChIKey=UVWYZZZSVYFDEY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475093   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475093BDBM475093(US10851082, NUCC-0054131)
Affinity DataIC50: 2.10E+3nMAssay Description:The synthesized compounds then were tested for inhibition of the kinase activity (IC50) of Mnk1 and/or Mnk2 using the ADP monitoring assay for kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475093BDBM475093(US10851082, NUCC-0054131)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK2 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min by ADP-Glo k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475093BDBM475093(US10851082, NUCC-0054131)
Affinity DataIC50: 6.00E+3nMAssay Description:The synthesized compounds then were tested for inhibition of the kinase activity (IC50) of Mnk1 and/or Mnk2 using the ADP monitoring assay for kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475093BDBM475093(US10851082, NUCC-0054131)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK1 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed