BDBM475207 US10851082, NUCC-0175697::US10851082, NUCC-0200980

SMILES Clc1cnc(NCCc2ccncc2)nc1-n1cnc2ccccc12

InChI Key InChIKey=AFKOJENZZZUAJE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 475207   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475207BDBM475207(US10851082, NUCC-0175697 | US10851082, NUCC-020098...)
Affinity DataIC50: 2.30nMAssay Description:The synthesized compounds then were tested for inhibition of the kinase activity (IC50) of Mnk1 and/or Mnk2 using the ADP monitoring assay for kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475207BDBM475207(US10851082, NUCC-0175697 | US10851082, NUCC-020098...)
Affinity DataIC50: 20nMAssay Description:The synthesized compounds then were tested for inhibition of the kinase activity (IC50) of Mnk1 and/or Mnk2 using the ADP monitoring assay for kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475207BDBM475207(US10851082, NUCC-0175697 | US10851082, NUCC-020098...)
Affinity DataIC50: 900nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK2 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min by ADP-Glo k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475207BDBM475207(US10851082, NUCC-0175697 | US10851082, NUCC-020098...)
Affinity DataIC50: 1.00E+3nMAssay Description:The synthesized compounds then were tested for inhibition of the kinase activity (IC50) of Mnk1 and/or Mnk2 using the ADP monitoring assay for kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475207BDBM475207(US10851082, NUCC-0175697 | US10851082, NUCC-020098...)
Affinity DataIC50: 5.50E+3nMAssay Description:The synthesized compounds then were tested for inhibition of the kinase activity (IC50) of Mnk1 and/or Mnk2 using the ADP monitoring assay for kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475207BDBM475207(US10851082, NUCC-0175697 | US10851082, NUCC-020098...)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK1 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed