BDBM476349 2-chlorophenyl (3S)-3-{[4- (aminomethyl)benzyl]carbamoyl}-4- (N,3-dicyclohexyl-D- alanyl)piperazine-1-carboxylate::US10875851, Example 5

SMILES NCc1ccc(CNC(=O)[C@@H]2CN(CCN2C(=O)[C@@H](CC2CCCCC2)NC2CCCCC2)C(=O)Oc2ccccc2Cl)cc1

InChI Key InChIKey=FDJNZLNJNHFXTA-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476349   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476349BDBM476349(2-chlorophenyl (3S)-3-{[4- (aminomethyl)benzyl]car...)
Affinity DataIC50: 5.90nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent